Additional heart failure markers: ANF, BNP, and Myh7 were also found to be significantly lowered in TAM-CAMCAKT mice compared to controls after 5 months of HFFD (p < 0.05, < 0.01, < 0.0001, < 0.001, < 0.01) (Fig. 4D). The gene discussed is NPPB; the disease is heart failure.