AGTR1 and hepatocellular carcinoma: An in vitro study by Oura et al. indicated that Telmisatan can inhibit the proliferation of HCC and induce cell cycle arrest [254].The use of an AT1R inhibitor (Irbesartan) and an ACE inhibitor (Captopril) in a mice model of CRC liver metastasis further elucidated the role of Ang II/AT1R signaling in the induction of metastasis [169].