Further studies on the physiological effects of the alamandine/MrgD seem necessary and can be helpful in better understanding of the downstream of this pathway and the effects it probably has beyond the cardiovascular system effects, such as possible anti-proliferative effect, anti-cancer effect, etc. It has been reported that alamandine can induce a shift in anaerobic metabolism to aerobic metabolism in tumor cells, negatively regulate PI3K/AKT/mTOR signaling pathway, and activate FoxO1 transcriptional factor. The gene discussed is AKT1; the disease is cancer.