In a study by Nakumara et al.the abrogation of Ang II effect via AT1R by receptor blockade or AGT (Angiotensinogen)-silenced breast tumor cells decreased the infiltration of macrophage and fibroblasts into tumor regions and further improved tumor response to immune-checkpoint inhibitors such as programmed cell death protein 1 (anti-PD-1) [143, 199, 225]. This evidence concerns the gene AGT and neoplasm.