An examination of RNF149 mRNA levels in MM cell lines HL-60, MOLM13, THP-1, Kasumi-1, MV4-11, KG-1, and the control cell HS-5 demonstrated that the expression in AML cell lines was notably elevated compared to HS-5 cells, particularly in MOLM13 and MV4-11 (Fig. 10B). Here, RNF149 is linked to acute myeloid leukemia.