A further confirmation supporting the pro-tumorigenic role of NLRP3 was obtained in a study led by Wang et al., showing a synergistic cooperation between the mammalian target of rapamycin (mTOR)-Ribosomal protein S6 kinase beta-1 (S6K1)-MAPK and NLRP3 signaling pathways, ultimately promoting the invasion of CRC cells [125]. The gene discussed is RPS6KB1; the disease is colorectal carcinoma.