The combination of OLT1177 and dexamethasone affects the nuclear and mitochondrial isoforms of the signal transducer and activator of transcription 3 (STAT3), capable to shrink tumor growth [180]; alternatively, Tranilast, although though indirect links with NLRP3 inflammasome, has been proposed to inhibit melanoma cell proliferation by activating CD8+ T cells [181]. This evidence concerns the gene NLRP3 and melanoma.