Although the overarching trend of these data suggested a pro-tumorigenic function of the NLRP3 pathway in GC, a more recent genetic profiling revealed that GC is characterized by the absence of GSDMD, whose overexpression significantly inhibits the growth and the proliferation of cancerous cells by arresting the S to G2/M phase transition [113]. The gene discussed is GSDMD; the disease is gastric cancer.