NLRP3 and inflammatory bowel disease: Data from genome-wide association studies (GWAS) have pointed out several hypofunctional NLRP3 polymorphisms (SNPs) associated with the development of IBD, such as rs10733113 found in CD [24] or rs10754558 found in UC [25], suggesting a protective role of the NLRP3 inflammasome against the pathogenesis of IBD.