Oncogenic mutants of kristen rat sarcoma viral oncogene homolog (KRAS) lead to ROS production, NLRP3 activation, IL-1β production and myeloproliferation phenotype in a myeloid leukemia mouse model by varying the proportion between cytoplasmic MYC proto-oncogene/tumor protein p53 (c-myc/TP53) and B-cell lymphoma 2/Bcl-2 Associated X-protein (bcl-2/bax) [190, 191]. Here, BCL2 is linked to myeloid leukemia.