Although TAMs within breast cancer (BC) microenvironment retain surprisingly low level of intracellular NLRP3, this aggressive neoplasm, which still represents the leading cause of mortality in woman, is characterized by an abundant population of CAFs, which promptly sense DAMPs and trigger the immune response through a robust activation of the NLRP3 inflammasome [169]. Here, NLRP3 is linked to breast carcinoma.