CASP1 and pancreatic neoplasm: By applying the MCC950 compound on NLRP3 inflammasome-induced cultured pancreatic cancer cell lines, Yaw and colleague showed a reduction of cell viability [158], whereas intraperitoneal injection on mice implanted of Panc02 cancer cells manifested a drastic suppression of platelets Caspase-1 activity, usually upregulated in pancreatic cancer [151].