Finally, Oridonin-Loaded Nanoparticles and Tranilast administration have been reported to reduce BC cell migration and invasion, alongside tumor progression, by modulating nuclear factor erythroid 2–related factor 2 (Nrf2) signaling and C-X-C motif chemokine receptor 4 (CXCR4) expression, respectively [173, 174]. This evidence concerns the gene CXCR4 and breast cancer.