NSCLC-derived exosomal tripartite motif containing 69 (TRIM69) protein has been shown to switch TAMs toward a pro-tumoral phenotype by physically interacting and downregulating abhydrolase domain containing 5 (ABHD5) protein, which, in turn, exacerbates NLRP3 inflammasome activation and, consequently, inducing cellular proliferation and invasion [176]. The gene discussed is TRIM69; the disease is non-small cell lung carcinoma.