PHIP and Hypoglycemia: Phip encodes for a protein that binds to the insulin receptor substrate 1 (Irs1) and is hypothesized to act as a link between Irs1 and the insulin receptor, thus modulating the insulin pathway [33, 34]; mice lacking Phip1, the main isoform of Phip, develop hypoglycemia and have a short lifespan [35].