In particular, Rgs6 is reportedly the only member of the Rgs family able to inhibit the function of different receptors involved in neurotransmission, and for this reason its deletion is associated with phenotypes ranging from problems with the parasympathetic regulation of the heart rate to neuropsychiatric disorders [96–98]; loss-of-function mutations in this gene can also lead to cancer growth, due to the inactivation of its tumor-suppressing ability [99]. This evidence concerns the gene PITX2 and neoplasm.