Similarly, while a dysregulated IFN-γ response is also a feature shared between MIS-C and SLE [11–14], the activity of type I and type III interferons has so far only been shown in SLE and rare inborn autoinflammatory disorders [15, 16], but not in MIS-C, even though antibodies against type I interferons have been shown to contribute to COVID-19 mortality and severity [17]. Here, IFNG is linked to COVID-19.