To analyze the hyperinflammatory signature of MIS-C, we measured IFN-α, IFN-γ, and IFN-λ in the serum of 50 patients with MIS-C sampled shortly after admission to hospital, before administration of immunosuppressive therapy, and compared them to the sera of healthy children who underwent COVID-19 cca 6 weeks prior to sampling and had no signs of MIS-C. Here, IFNG is linked to COVID-19.