SET KD had a stronger impact on KMT2A-wt AML cell line Kasumi1 (Fig. 2M, Supplementary Fig. 3 and Supplementary Table 2) and on KMT2A-wt ALL cell line REH (Fig. 2N, Supplementary Fig. 3 and Supplementary Table 2). This evidence concerns the gene KMT2A and acute lymphoblastic leukemia.