The DOT1L phosphosites Ser900 and Ser1104, identified as dephosphorylated by siSET in the study by Aaakula et al., were also found dephosphorylated by FTY720 in THP1 (Supplementary Table 2), supporting the concept that SET mediates its anti-tumor effects though modulation of relevant epigenetic factors. Here, DOT1L is linked to neoplasm.