To further substantiate the role of SET in AML, we evaluated its protein levels by western blot in a panel of KMT2A-R-AML (THP1, MV411, ML2, MOLM13, NOMO-1) and KMT2A-R-ALL (SEM, Hb1119, KOPN8, RS411) cell lines and primary samples (PS), KMT2A wild-type (wt) cell lines (K562, BCR::ABL+ erythroleukemia, Kasumi1 AML1::ETO + AML, REH TEL::AML + ALL, U937 CALM::AF10 + AML), mononuclear cells isolated from the bone marrow (BM) and peripheral blood (PB) of healthy adult volunteers. Here, SET is linked to acute lymphoblastic leukemia.