More importantly the RNA-seq data indicated that, upon FTY720 treatment, several genes overexpressed in cancer, including MYC and SET were downregulated (Supplementary Table 6), as well as genes associated with histone methyltransferase activity, among which several members of the KMT2A- fusion epigenetic complex, and HOXA9/MEIS1 target genes [3, 8–10] (Supplementary Table 7). This evidence concerns the gene MYC and cancer.