Our study results demonstrated that in progressed T2DM patients already on insulin treatment in outpatient settings, neither detrimental nor beneficial effects were exerted by DPP-4 inhibitor comedication in terms of infection risks, whereas those exposed to SGLT-2 inhibitors were at higher risk of genital infections when compared against those using metformin as comedication. Here, SLC5A2 is linked to type 2 diabetes mellitus.