The incidence of genital infections was higher with SGLT-2 inhibitor + insulin therapy than with metformin + insulin combination in the following strata: ≥ 80 years of age, male, and comorbid conditions of renal disease and cancer at baseline, but risk analyses were not performed due to the scarcity of endpoint events as well as the limited sample size of these strata. The gene discussed is INS; the disease is cancer.