In this study, the skin necrosis group revealed significantly higher incidences of elevated APACHE score, postoperative intubation, ICU stay, shock at ER, leukopenia, higher banded leukocytes, elevated CRP, and hypoalbuminia than non-skin necrosis group, which indicate that NF patients with initial skin necrosis presentation at ER experienced more fulminant clinical courses and higher mortality rate than those NF patients without skin necrosis. Here, CRP is linked to Decreased total leukocyte count.