ADA and chronic granulomatous disease: However, genome-editing-based treatments using γRV of Chronic granulomatous disease (CGD)37, Wiskott-Aldrich syndrome (WAS)38,39, SCID-X140, and Adenosine deaminase (ADA)-SCID41 resulted in the activation of proto-oncogenes leading, in some patients, to a leukemic transformation42,43.