This signal enhancement was also observed at the pathway level, where a TimeAx based analysis identified stronger associations for known cancer-related processes such as the epithelial-mesenchymal transition (EMT)18,19, TNFα signaling20, interferon gamma21 and G2/M cell cycle checkpoint22 (Fig. S3B, see Methods; q < 10−48, q < 10−25, q < 10−19 and q < 10−9, respectively). This evidence concerns the gene TNF and cancer.