The loss-of-functions of ABCC transporters, including ABCC1 (MRP1) and ABCC6, are associated with enhanced susceptibility to drug toxicity and ectopic mineralization, respectively, while the Cystic Fibrosis Transmembrane conductance Regulator (CFTR/ABCC7) anion channel deficiency leads to cystic fibrosis (CF), the most prevalent lethal genetic disease in Caucasian populations5,6. Here, ABCC1 is linked to hereditary disease.