APC and dysplasia: In the matched GC-dysplasia pairs, the majority of driver gene mutations (22/26) observed in the GCs were also observed in the patient-matched dysplasia (e.g., TP53, APC, ARID1A) (Figure 2E), with most pairs (23/28) showing at least one shared mutation between dysplastic lesions and matched GCs (Figure 2F).