IRF1 and acute myeloid leukemia: It should, however, be noted that some of the comparisons between our results in mouse HSCs and human AML are challenging because of a whole-body IRF1 KO environment versus high and low IRF1 gene expression in hematopoietic cells, steady-state murine conditions versus a full-blown perturbed leukemic context, and differences in the specific cell type(s) being investigated.