Increased IR downregulates gene expression and is considered a post-transcriptional signature associated with neurological diseases.47,58 We found 54 DRIs in ASD genes, such as BAZ2B, CORO1A, ELAVL3, and VAMP2. The 3′-terminal intron of VAMP2 was partially included in progenitors but not in neurons (Figure S5E). This evidence concerns the gene ELAVL3 and nervous system disorder.