For example, we identified 13 FSM, 8 NIC, and 8 ISM isoforms in the PTEN gene, which is a tumor suppressor and one of the most extensively studied autism genes.32 Analyses of predicted protein sequences suggest that the previously unannotated PTEN splice forms may lead to the deletion of the catalytic N-terminal phosphatase domain or the shortening of the C2 domain (Figure 1G). This evidence concerns the gene PTEN and autism.