RBFOX1 and Intellectual disability: Mutations in AS regulators such as RBFOX1 have been shown to cause ASD and intellectual disability.9 Comparisons of postmortem brains from patients with ASD and healthy donors uncovered dysregulated AS networks controlled by RBFOX1, nSR100, or PTBP2 proteins.10-13 On the other hand, ASD genes have been reported to express different isoforms that are important for neural development and synaptic connectivity.14