The CS-GM-induced Th2 biased immune response may likely have a more profound impact on allergic diseases driven mainly by Th2 cells and a high IgE response such as allergic asthma and food allergy rather than AD that has a more complex pathogenesis likely requiring more environmental factors involved other than microbiota dependent Th1/Th2 imbalance. Here, IGHE is linked to allergic asthma.