VEGFA and cancer: According to a study conducted by Feliciano et al. in 2012, the maximum vascular velocity in malignant tumors tends to be higher (28.71 cm/s), in contrast to benign mammary tumors that present lower velocity (19.91 cm/s), in addition to having a positive correlation between vascular endothelial growth factor (VEGF) and the presence of tumor vascularization and maximum velocity (Figure 2) [40].