Furthermore, univariate and multivariate Cox regression analysis showed that SLC35A2 was overexpressed (HR = 1.548, 95% CI = 1.049–2.285; p = 0.028), N1 (HR = 0.272, 95% CI = 0.097–0.763; p = 0.013), and pathological stage III (HR = 12.509, 95% CI = 2.118–73.860; p = 0.005) was independently correlated with OS in CRC patients. This evidence concerns the gene SLC35A2 and colorectal carcinoma.