We also found that CKD increased the levels of insoluble RNA-binding proteins, such as small nuclear ribonucleoprotein U1 subunit 70 (SNRNP70) and other core U1 small nuclear ribonucleoproteins (snRNPs), which are strongly correlated to the pathology of tau insolubility in AD [11, 25, 26]. The gene discussed is MAPT; the disease is chronic kidney disease.