al, in a study of 152 elderly patients with symptomatic severe aorticstenosis undergoing TAVI, showed a 40% occurrence of SIRS during the first 48 hoursafter the procedure, characterized by a significantly elevated release of IL-6 andIL-8, with subsequent increase in leukocytes, CRP, and PCT[16]. The gene discussed is IL6; the disease is systemic inflammatory response syndrome.