In contrast, aberrant hypermethylation of HNF1A downregulates the expression of UDP-glucuronosyltransferase 1A1 (UGT1A1), which remodels drug metabolism and transport pathways, locally inactivating anticancer drugs by glucuronidation in colon cancer cells [24]. The gene discussed is UGT1A1; the disease is malignant colon neoplasm.