When HCT116 + Fn + Cys was compared with HCT116 group (Fig. 4b bottom), NOD-like receptor signaling pathway, AGE-RAGE signaling pathway in diabetic complication, human T-cell leukemia virus 1 infection, salmonella infection, TNF signaling pathway and NF-κB signaling pathway, apoptosis and focal adhesion and mitophagy were all up-regulated in HCT116 + Fn + Cys group. Here, FN1 is linked to Salmonella Infections.