The Venn diagram shows that the genes with different expression between the HCT116 + Fn group and the HCT116 + Fn + Cys group are TMEM238, CCL20, DNAJB9, etc. Moreover, the HCT116 + Fn + Cys group had far more differentially expressed genes when compared with the HCT116 group than the HCT116 + Fn group when compared with the HCT116 group, further suggesting that Fn plays a role in promoting cancer development, and H2S further enhanced the expression of pro-oncogenes. The gene discussed is TMEM238; the disease is cancer.