Several studies have shown that histone acetylation induced by HDAC inhibitors promotes the differentiation of t(8;21) leukemia.[21] We found that HDAC inhibitors trichostatin A and panobinostat induced differentiation and apoptosis of t(8; 21) leukemia cells as well as reducing the level of AML1‐ETO protein (Figures S16A–D and S17A–D, Supporting Information). This evidence concerns the gene RUNX1 and leukemia.