RUNX1 and leukemia: Genome abnormalities caused by chromosomal translocations play a key role in the development of leukemia.[1] The t(8;21) chromosomal translocation generated a chimeric gene encoding AML1‐ETO oncoprotein that contains the N‐terminal DNA‐binding domain of acute myeloid leukemia 1 (AML1) gene and nearly full‐length eight‐twenty one (ETO) gene.