It has been reported that AML1‐ETO inhibits the expression of PU.1 and C/EBPα, two important transcription factors for the differentiation of myeloid cells, thereby preventing the differentiation of t(8,21) type leukemia cells.[4, 5] Interestingly, V9‐HFn‐Se increased the expressions of PU.1 and C/EBPα in Kasumi‐1 cells (Figure 5A–F). Here, SPI1 is linked to leukemia.