Moreover, USP4 protects TRAF6 from degradation and reduces enterovirus 71 (EV71) replication.[214] DUB screening and biochemical analyses showed that OTUD4 removes Lys48‐linked Ub‐chain of MAVS, thereby limiting MAVS proteasomal degradation and activating downstream signaling in response to viral infection.[215]. This evidence concerns the gene TRAF6 and viral infectious disease.