Whereas, some DUBs play a Janus‐faced role in pro‐/anti‐apoptois of cancer, including UCHL5, USP2, USP4, USP7, USP9X, USP10, and USP14.[153, 154] The reasons for the opposing roles depend on diverse functions of linkage type for deubiquitination, selective protein substrates associated with oncogenic or tumor suppressive effect, individual interactome, and an ever‐changing microenvironment. This evidence concerns the gene USP10 and neoplasm.