In addition, USP7 and USP21 enhance GATA3‐regulated activity in FOXP3‐expressing cells.[258] USP21 deficiency in Treg cells reduces FOXP3 expression, which reconciles the expression of Treg signature genes, and diminishes their suppressive activity.[259] Treg cells limit antitumor immune responses and facilitate tumor survival, therefore, anticancer immunotherapies recommend FOXP3 depletion in Treg cells by targeting USP7 and USP21. This evidence concerns the gene USP7 and neoplasm.