This promotes MDM4 accumulation in the cytoplasm and mitochondria, p53 phosphorylation, and mitochondrial‐mediated apoptosis.[140] UCHL1 forms a complex with p53/p14 ARF/ MDM2 to deubiquitinates p53, and p14 ARF for p53 signaling and apoptosis triggering in nasopharyngeal carcinoma and breast cancer.[141, 142] USP10 is another DUB with a pro‐apoptosis function; it modulates phosphatase and tensin homolog (PTEN) in lung and breast cancer cell lines.[143] Knockdown of USP10 promotes tumor growth, invasion, and metastasis antagonized by PTEN overexpression (Figure 6C).[143]. This evidence concerns the gene CDKN2A and breast cancer.