SPATA2 and neoplasm: USP7 stabilizes the expression of Forkhead box protein P3 (FOXP3), thus enhancing the regulatory T cell (Treg) suppressive capacity facilitated by this critical transcription factor.[256] USP7 depletion prompts the polarization of TAMs (tumor‐associated macrophages) from M2 into M1 by stimulating the P38 MAPK pathway and enhancing the expression of immune checkpoint molecule programmed death ligand 1 (PD‐L1) in the tumor microenvironment.[257] Accordingly, USP7 inhibition integrated with anti‐PD‐1 immunotherapy could exert a more effective inhibitory effect on tumors.