To understand if FXR is involved in the metabolic syndromes attributed to arsenic exposure, we exposed FXRKO and WT mice to arsenic in drinking water (Figure 1A) and observed more severe glucose intolerance in FXRKO mice (Figure 2), which served as the initial evidence of the involvement of FXR in arsenic metabolic disturbance. The gene discussed is NR1H4; the disease is Glucose intolerance.