KEGG analysis of DEGs revealed that ZEN mainly affected signaling pathways related to human diseases and environmental information processes such as MicroRNAs in cancer, the PI3K-Akt and JAK-STAT signaling pathways, systemic lupus erythematosus, the TGF-beta signaling pathway, and extracellular matrix-receptor interactions (Figure 2E). This evidence concerns the gene AKT1 and systemic lupus erythematosus.