TRIM39 and cancer: Previously, it was shown that mambalgin-2, the three-finger protein (TFP, [47]) from the Mamba venom initially described as the inhibitor of the ASIC1a channels [48], interacts with the heterotrimeric α-ENaC/ASIC1a/γ-ENaC channels in various cancer cells, and this interaction results in control of the homeostasis of cancer cells [25,35].