The metabolism category includes lysine degradation, cysteine and methionine metabolism, the Pentose phosphate pathway, etc. Human diseases mainly include microRNAs in cancer, insulin resistance, the AGE−RAGE signaling pathway in diabetic complications, etc. Genetic information processing mainly includes ribosomes, proteasomes, etc. Environmental information processing mainly includes the FoxO signaling pathway, the HIF−1 signaling pathway, the Hippo signaling pathway of multiple species, etc. The main cellular processes include the p53 signaling pathway and ferroptosis, etc. The gene discussed is TP53; the disease is cancer.