Moreover, inhibition of GSK3B, a constitutively active protein kinase that acts as a negative regulator of glucose homeostasis, Wnt signaling, and regulation of transcription factors and microtubules have been clinically investigated in advanced solid malignancies (NCT03678883) and leukemia (NCT01214603, NCT01632306), yielding promising results (Park et al., 2021). Here, GSK3B is linked to leukemia.