On the contrary, signal transduction pathways associated with GPCR (R‐HSA‐388396), EGFR (R‐HSA‐177929), and MAPK1/MAPK3 signaling (R‐HSA‐5684996) were predominantly downregulated in both aging and cancer (Figure 3b and Table S5). The gene discussed is MAPK1; the disease is cancer.