FGF2 and periodontal disorder: Treatment methods for periodontal tissue regeneration based on cell biological concepts have been established in the field of periodontology using cell biological agents, including an enamel matrix derivative (Emdogain®: Kaken Pharmaceutical, Tokyo, Japan) [30] and basic fibroblast growth factor (FGF-2, REGROTH®: Strauman Japan, Tokyo, Japan) [31], as well as changing the passive treatment of periodontal diseases to a proactive therapeutic method.