CRP and bacterial infectious disease: Having said that, early diagnostic markers for bacterial infections are also in practice, such as checking procalcitonin (PCT), C-reactive protein (CRP), and interleukin-6 (Il-6) levels [57] to detect a bacterial infection at an early stage and to assess the prognosis of the disease, whilst continuous updates on diagnostic guidelines are being well received in the era of dynamic knowledge exchange and information access [58].