Rare variants have been identified in the ADIPOQ, ADRB3, APLN, APLNR, FTO, GCG, GLP1R, GHRL, GIP, INS, LEP, NAMPT, PPY, PYY, RETN, and SCT genes in young adults with abdominal obesity. The gene discussed is APLNR; the disease is Abdominal obesity.