Amborgi et al. showed that TROP-2 is an unfavorable prognostic factor when localized in the membrane of breast cancer cells in terms of overall survival (HR = 1.63, p = 0.04), whereas a favorable effect was observed in intracellular expression (HR = 0.48, p = 0.003) [28]. The gene discussed is TACSTD2; the disease is breast carcinoma.