SLC5A2 and heart failure: While this is an inherent limitation for any long-term study because new medications may well be introduced during the five years of follow-up, the impact on the results of this study is likely very modest, as sodium-glucose cotransporter-2 inhibitors decrease heart failure and other cardiac events with minimal impact on survival [25], and heart failure risk models such as the SHFM have been shown to perform equally well in studies of angiotensin-neprilysin inhibitors [26] compared with other cohorts.