In addition, the combinations of ICIs and VEGFR-TKIs reduce the overall treatment tolerability, due to cumulative adverse events, which, in some cases, can even reinforce each other (e.g., immune-mediated colitis and VEGFR-TKI-induced diarrhea or ICI-induced myocarditis and VEGFR-TKI-mediated microvascular damage) [6]. Here, KDR is linked to myocarditis.