In addition, risk stratification at the time of diagnosis is based on MYCN amplification status (an MYCN copy number increase is strongly linked to poor prognosis), ploidy, stage, age, and segmental chromosomal alteration status (e.g., 11q loss), and it is noteworthy that close to half of all cases of NB are categorised as high-risk and only half of these cases achieve long-term survival [4,9,10]. Here, MYCN is linked to neuroblastoma.