A separate comparison of stage II and III lipedema with the control group resulted in a significant overexpression of CD74 in stage II lipedema (mean 1.703; SD 0.3959; p = 0.0071) and a significant overexpression of MIF-1 in stage III lipedema (mean 1.370; SD 0.3266; p = 0.0383). This evidence concerns the gene HERPUD1 and Lipedema.