During acute hypoglycemia, people with type 1 diabetes have an increased CD40 expression on monocytes and plasma sCD40L concentrations and an upregulation of the intracellular adhesion molecule (ICAM), vascular cell adhesion molecule (VCAM), E-selectin, and vascular endothelial growth factor (VEGF) [133]. The gene discussed is VEGFA; the disease is type 1 diabetes mellitus.