Apoptosis was also observed in action for CuB in cancer cells via inhibition of the IL-6/STAT3 pathway [104], via modulating the miR-17-5p/STAT 3 [106], and for CuI via down-regulation of the PI3K/AKT/p70S6K pathway [130] in lung cancer cells. The gene discussed is STAT3; the disease is lung cancer.