To further investigate the mechanisms by which mutant p53R248Q contributes to cancer development, we performed an analysis of validated target genes using the miRPath algorithm, which identified multiple genes involved, especially in pathways such as Cell cycle (58 miRNAs/85 genes), Adherens junction (55 miRNAs/61 genes), Pathways in cancer (62 miRNAs/228 genes), p53 signaling pathway (50 miRNAs/49 genes), MAPK signaling pathway (54 miRNAs/84 genes), and Focal adhesion (63 miRNAs/126 genes) (Figure 3c, Supplementary Table S9). This evidence concerns the gene TP53 and cancer.