This evidence from zebrafish is consistent with results in rats, showing that prenatal injection of Cxcl12, the chemokine ligand of Cxcr4, induces behaviors similar to prenatal alcohol exposure, including an increase in novelty-induced locomotor activity and anxiety [24], and that neuronal chemokines, including Cxcl12 and its Cxcr4 receptor, are markedly stimulated by prenatal alcohol exposure [176,177,244] and are involved in alcohol-related behaviors [24,245,246]. The gene discussed is CXCL12; the disease is Anxiety.