The physical interaction between LAT1 and Rictor, along with the activation of downstream targets of mTORC2, provides a foundational molecular understanding of the pivotal role played by LAT1 in cancer cell migration (Figure 5), the elevated LAT1 expression in metastatic sites compared to primary sites [5], and the lower survival rates observed in patients with higher LAT1 expression levels [53]. The gene discussed is SLC7A5; the disease is cancer.