In addition to their resistance to I/R-induced renal injury, αMUPA female mice did not exhibit significant increases in renal inflammatory and fibrotic markers, including IL-6, TLR4, and TGF-β, as well as circulatory proinflammatory cytokine levels following AKI when compared to WT mice and αMUPA males. This evidence concerns the gene TGFB1 and acute kidney injury.