While treated αMUPA female animals did not exhibit significant changes in renal inflammatory and fibrotic markers such as IL-6, STAT3, p-STAT3, and TGF-β following AKI, in contrast to their male counterparts and WT mice, these proinflammatory and fibrotic markers showed elevation after AF498 injection in αMUPA female mice. Here, STAT3 is linked to acute kidney injury.