In addition to their resistance to I/R-induced renal injury, αMUPA female mice did not exhibit significant increases in renal inflammatory and fibrotic markers, including IL-6, TLR4, and TGF-β, as well as circulatory proinflammatory cytokine levels following AKI when compared to WT mice and αMUPA males. Here, TLR4 is linked to acute kidney injury.