Researchers found that PBMC collected from patients diagnosed with SLE and with Toll-like receptor 7 (TLR7) rs3853839 C/G polymorphism had higher TLR7 expression and signaling than healthy controls, which promoted the production of autoantibodies by newly formed transitional B cells leading to autoreactivity, antibody activation and damage to tissues [90]. The gene discussed is TLR7; the disease is systemic lupus erythematosus.