Particularly interesting to us were those factors that are differentially expressed both in the transcriptomic and proteomic profiling, but which were not previously reported to be altered in Mct8/Oatp1c1 deficiency and may thus advance our understanding of the yet elusive pathways underlying the pathological alterations in AHDS. Here, SLCO1C1 is linked to Allan-Herndon-Dudley syndrome.