The prevention of phagophore nucleation through the deletion of BECN1 or pharmacologic inhibition of the class III PI3K complex by 3-MA attenuates lipid degradation, reduces FAO and decreases the basal and ATP-linked oxygen consumption rate (OCR, indicator of mitochondrial respiration) in the acute myeloblastic leukemia (AML) cell line MOLM14 [85]. The gene discussed is BECN1; the disease is acute myeloid leukemia.