An interesting link between HK2 levels and autophagic flux has been reported in liver cancer cell lines: cells with low autophagic flux exhibited high expression of HK2 and a high glycolysis phenotype, while cells with high autophagic flux acquired a low-glycolysis phenotype because HK2 is degraded by p62/SQSTM1-mediated autophagy [111] and CMA [121]. Here, HK2 is linked to liver cancer.