PKM2, a key mediator for the Warburg effect [80], increases the phosphorylation of BECN1 and contributes to cell survival via autophagic activation in a nucleophosmin-mutated AML cell line, where PKM2 knockdown reduces the phosphorylation of BECN1 at T119 [81]. The gene discussed is BECN1; the disease is acute myeloid leukemia.