Inhibition of glycolysis with 2-Deoxy-D-glucose (2-DG), a glucose analog that inhibits the function of HK2 and G6P isomerase [125], in combination with the autophagy inducer rapamycin prevents the induction of cell death caused by 2-DG in pancreatic and breast cancer [126], as well as neuroblastoma and colon carcinoma [127] cell lines. The gene discussed is HK2; the disease is neuroblastoma.