Consistent with this additive or synergistic effect of the pharmacological inhibition of glycolysis and inhibition of the initial steps of autophagy, blocking the autophagic flux with CQ in combination with the glucose transporter (GLUT) inhibitor silibinin enhances apoptosis induction in glioblastoma cell lines [134] and, likewise, 3-BrPA or 2-DG in breast cancer [129] and glioblastoma [135] cell lines, respectively. The gene discussed is SLC2A1; the disease is glioblastoma.