On the other hand, the use of metformin, a drug that inhibits HK2 and mitochondrial complex I [136,137], in co-treatment with autophagy inhibitors rescues cells from metformin-mediated cytotoxicity: AMPK inhibitor compound C or AMPK knockdown decreases growth inhibition and cell cycle arrest in B-lymphoma and T-lymphoma cell lines [138]. The gene discussed is PRKAA1; the disease is lymphoma.