MYC and meningioma: GSEA and in silico pathway analyses of the integrated data unraveled the complexity by identifying alterations in signaling cascades in advanced grade meningioma, which primarily included extracellular matrix organization, integrin binding pathways, the spliceosome, and ECM proteoglycans on the one hand, and hallmark gene sets like apoptosis, angiogenesis, E2F, and Myc targets on the other.