The long-term misuse of alcohol does not only impact the brain and gut but also affects other organs, such as the liver, spleen, pancreas, kidneys, etc. In the liver, heavy alcohol drinking causes several alcohol-related liver diseases by virtue of the fact that this drug-metabolizing organ consists of alcohol-breaking machinery, including alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH2), cytochrome P450 2E1 (CYP2E1), and catalase [156]. The gene discussed is CYP2E1; the disease is liver disorder.