IL20 and Alzheimer disease: When examining disease-driven changes of IL-20 and its cognate receptor subunits in skin from healthy human subjects, atopic dermatitis (AD) patients and murine AD models, the authors highlighted a role of IL-20 signaling in the pathophysiology of AD, thus forming a new basis for the development of a novel antipruritic strategy via interrupting IL-20 epidermal pathways [27].