For example, the potential contributions of abundant xenoestrogens such as bisphenols and dietary soy isoflavones in breast cancer have been dismissed largely due to their low relative binding affinities (RBAs) for ERα, even though many of these exhibit significantly higher RBAs for GPER, and this has been previously described [6,13,39,81]. This evidence concerns the gene GPER1 and breast carcinoma.